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Various

"Scientific American Supplement, No. 458, October 11, 1884"

Alcohol first checks the development of the comma
bacilli when it is mixed with the nutrient fluid in the proportion of 1 in
10, a degree of concentration which renders it impracticable for
treatment. Common salt was added to the extent of 2 per cent. without
influencing the growth of the bacilli. Sulphate of iron, in the proportion
of 2 per cent., checks this growth, probably by precipitating albumimites
from the fluids, and possibly also by its acid reaction; certainly it does
not seem to have any specific disinfecting action--i.e., in destroying the
bacilli. Indeed, Koch thinks that the admixture of sulphate of iron with
faecal matter may arrest putrefaction, and really remove what may be the
most destructive process to the comma bacilli. Hence he would distinguish
between substances which merely arrest putrefaction and those which are
bactericidal; for the former may simply serve the purpose of preserving
the infective virus. Among other substances which prevent the growth of
the comma bacilli may be mentioned alum, in solutions of the strength of 1
in 100; camphor, 1 in 300; carbolic acid, 1 in 400; oil of peppermint, 1
in 2,000; sulphate of copper, 1 in 2,500 (a remedy much employed, but how
much would really be needed merely to hinder the growth of the bacilli in
the intestine!); quinine, 1 in 5,000; and sublimate, 1 in 100,000.


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